Leukotriene Receptor Antegonist. 4. Synthesis and Leukotriene D4/E4 Receptor Antagonist Activity of 4-(Alkyl)acetophenone Derivatives

DOI: 10.1021/jm00396a027

Source and publish data:

Journal of Medicinal Chemistry p. 172 - 175 (1988)

Update date:2022-07-29

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Authors:

Gapinski, D. Mark

Roman, Carlos R.

Rinkema, Lynn E.

Fleisch, Jerome H.

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Article abstract of DOI:10.1021/jm00396a027

Analogues of the leukotriene D₄/E₄ receptor antagonist LY171883 (1a) were synthesized in which the tetrazole was linked to the hydroxyacetophenone moiety by an all-methylene carbon chain.A key step in the synthesis involved a Wittig

Full text of DOI:10.1021/jm00396a027

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