Toward the synthesis of isozyme-specific enzyme inhibitors. Potent inhibitors of rat methionine adenosyltransferases. Effect of one-atom elongation of the ribose-P(α) bridge in two covalent adducts of L-methionine and β,γ-imido-ATP

Article abstract of DOI:10.1021/jm00397a020

With 2',3'-O-isopropylideneadenosine or its N⁶-benzoyl derivative as starting material, synthetic routes to two novel adducts of L-methionine and β,γ-imido-ATP have been devised. One adduct, 14 (2:3 mixture of 6' epimers), had a P(α)OCH(R¹