Oxazoles Are Masked Carboxyls That Activate Ortho-Leaving Groups in Nucleophilic Aromatic Substitution

Article abstract of DOI:10.1246/cl.1987.19

Oxazoles substituted in their 2-positions with 2-methoxy-, 2-fluoro-, or 2,6-difluorophenyl groups, and in their 4,5-positions with methyls or phenyls, were treated with ArMgBr or ArLi to give substituted biphenyl or terphenyl products.The oxazole groups were subsequently converted to esters, acids, or amides.These reactions provide a new unsymmetrical aryl-aryl coupling synthon.