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Synthesis of methyl [6-(2-amino-1,3-thiazol-4-yl)-3-oxo-1,4-benzoxazin-2- yl]acetates as possible COX-2 / 5-LOX inhibitors

DOI: 10.1515/HC.2008.14.1-2.95

Source and publish data:

Heterocyclic Communications p. 95 - 100 (2008)

Update date:2022-07-30

Topics:

Authors:

Jagath ReddyJagath Reddy

Srinivasa RaoSrinivasa Rao

JayaveeraJayaveera

SailajaSailaja

ReddannaReddanna

Bharat ReddyBharat Reddy

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Article abstract of DOI:10.1515/HC.2008.14.1-2.95

A series of methyl [6-(2-aminothiazol-4-yl)-3-oxo-1,4-benzoxazin-2-yl] acetates (3-5) have been synthesized and tested for COX-2 (Cyclooxygenase) / 5-LOX (Lipoxygenase) inhibitory activity. Some of the compounds exhibited notable 5-LOX inhibitory activity.

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Full text of DOI:10.1515/HC.2008.14.1-2.95

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Download Date | 6/3/15 2:30 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/3/15 2:30 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/3/15 2:30 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/3/15 2:30 AM  
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Download Date | 6/3/15 2:30 AM  

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