Asymmetric Synthesis with Chiral β-Lactams. α-Substituted Aromatic α-Amino Acids and Their Derivatives through Highly Stereoselective Alkylations

Article abstract of DOI:10.1021/ja00209a044

A novel route to optically pure α-alkylated aromatic α-amino acids and their dipeptide derivatives was developed through the asymmetric alkylation at the C-3 position of a chiral β-lactam 1 followed by the reductive cleavage of the alkylated β-lactams 2.T