Synthesis of Trisubstituted Acrylic Acids through Nickel-Catalyzed Carbomagnesiation of Alkynes and Carbon Dioxide Fixation

Article abstract of DOI:10.1002/ejoc.201801364

A nickel-catalyzed synthesis of trisubstituted acrylic acids from alkynes, Grignard reagents, and CO₂ is reported. The reaction proceeds through carbomagnesiation of the alkyne with Grignard reagent followed by carboxylation with CO₂ under mild reaction conditions in short time. Various unsymmetrical alkynes were transformed into the corresponding acid products in good yields with high stereoselectivity.