Journal of Medicinal Chemistry p. 466 - 472 (1988)
Update date:2022-07-29
Topics: In vitro Derivatives Antagonists in vivo High-Throughput Screening Pharmacokinetics Experimental terms Assay Platelet Activating Factor Pharmacodynamics
Tilley, Jefferson W.
Burghardt, Barbara
Burghardt, Charles
Mowles, Thomas F.
Leinweber, Franz-Josef
et al.
A series of N-<(heteroaryl)alkyl>pyrido<2,1-b>quinazolines were evaluated for their ability to inhibit the binding of radiolabeled platelet activating factor (PAF) to its receptor on dog platelets.The most potent compounds in this series were found to be
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