THE ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS: SIDE CHAIN SPECIFICITY

DOI: 10.1016/S0040-4020(01)86840-X

Source and publish data:

Tetrahedron p. 3009 - 3014 (1987)

Update date:2022-08-04

Topics:

Authors:

Baldwin, Jack E.

Adlington, Robert M.

Crabbe, M. James

Knight, Graham

Nomoto, Takashi

et al. et al.

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Article abstract of DOI:10.1016/S0040-4020(01)86840-X

Structural variants of the acylamino side chain of penicillins have been tested as substrates for Deacetoxy/Deacetyl Cephalosporin C Synthetase from C. acremonium CO 728.A six carbon chain terminating in a carboxyl group was found to permit efficient ring expansion to cephems, with the exception of δ-(L-α-aminoadipoyl).

Full text of DOI:10.1016/S0040-4020(01)86840-X

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