Journal of Medicinal Chemistry p. 606 - 612 (1988)
Update date:2022-07-29
Topics:
Kelley, James L.
Krochmal, Mark P.
Linn, James A.
McLean, Ed W.
Soroko, Francis E.
Several 9-alkyl-6-substituted-purines were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats.Most compounds were prepared in three steps from 5-amino-4,6-dichloropyrimidine or in two steps via alkylation of 6-chloropurine.Potent anticonvulsant activity against MES resided in compounds that contain a benzyl substituent at the 9-position of 6-(methylamino)- or 6-(dimethylamino)purine.Among commonly used agents for control of seizures, this type of structure represents a new class of potent anticonvulsant agents.
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