Modular Tuning of Electrophilic Reactivity of Iridium Nitrenoids for the Intermolecular Selective α-Amidation of β-Keto Esters

Article abstract of DOI:10.1021/jacs.0c04344

We report herein an Ir-catalyzed intermolecular amino group transfer to β-keto esters (amides) to access α-aminocarbonyl products with excellent chemoselectivity. The key strategy was to engineer electrophilicity of the putative Ir-nitrenoids by tuning electronic property of the κ2-N,O chelating ligands, thus facilitating nucleophilic addition of enol π-bonds of 1,3-dicarbonyl substrates.

Full text of DOI:10.1021/jacs.0c04344

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Communication
Modular Tuning of Electrophilic Reactivity of Iridium Nitrenoids
for the Intermolecular Selective #-Amidation of #-Keto Esters
Minhan Lee, Hoimin Jung, Dongwook Kim, Jung-Woo Park, and Sukbok Chang
J. Am. Chem. Soc., Just Accepted Manuscript • DOI: 10.1021/jacs.0c04344 • Publication Date (Web): 30 Jun 2020
Downloaded from pubs.acs.org on July 1, 2020
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Corresponding Author
ORCID:
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REFERENCES
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