Intramolecular Friedel-Crafts Alkylation and Chloroalkylation of 5-Aryl-1,1,1-trifluoropentan-2-ones. A Route to (Trifluoromethyl)dihydronaphthalenes and (Trifluoromethyl)tetrahydronaphthalenes

DOI: 10.1021/jo00239a011

Source and publish data:

Journal of Organic Chemistry p. 759 - 762 (1988)

Update date:2022-08-04

Topics:

Authors:

Bonnet-Delpon, D.

Charpentier-Morize, M.

Jacquot, R.

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Article abstract of DOI:10.1021/jo00239a011

The Friedel-Crafts cyclization of some 5-aryl-1,1,1-trifluoropentan-2-ones yields selectively either 1-(trifluoromethyl)dihydronaphthalenes or 1-chloro-1-(trifluoromethyl)tetrahydronaphthalenes or 1-aryl-1-(trifluoromethyl)tetrahydronaphthalenes, depending on the solvent and the acid.

Full text of DOI:10.1021/jo00239a011

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