Methoxy(phenylthio)(trimethylsilyl)methane as a One-Carbon Homologation Reagent: Efficient 1,4-Addition of a Formyl or a Carboxy Anion Equivalent to Cyclic α-Enones Concomitant with in Situ α-Alkylation

Article abstract of DOI:10.1021/jo00282a010

Efficient 1,4-addition of a formyl and carboxy anion equivalent is realized by use of lithium.Of further synthetic value is consecutive α-alkylation by in situ trapping of intermediary enolates with various alkyl