The effect of lipophilic substituents on the H2-histaminergic activity of some close analogues of impromidine

Article abstract of DOI:10.1002/ardp.19923250805

The cimetidine-like moiety of the potent H₂-agonist impromidine (9a) and three closely related guanidines (10a, 11a, and 12a) which are modified in the imidazolylpropyl portion, has been replaced by 2-[(2-pyridyl)methylthio]ethyl, 2-(benzylthio