Chemical and Pharmaceutical Bulletin p. 582 - 587 (1995)
Update date:2022-08-04
Topics:
Kato
Morie
Ohno
Yoshida
Yoshida
Naruto
2-Alkoxy-4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-5-chlorobenzamides had been identified as the interesting members of a series of selective and potent gastroprokinetic agents. A new series of 2-amino- and 2-(substituted amino)-N-[(4-benzyl-2-morpholinyl)methyl]benzamides (13-35) has been synthesized and these compounds were examined to determine whether they have advantages over the 2-morpholinyl benzamides 1 with a 2-alkoxy group. The gastroprokinetic activity was generally reduced, but several compounds showed relatively:potent activity, comparable to that of the standard agent, metoclopramide. N-[(4-Benzyl-2-morpholinyl)methyl]-4-chloro-2-[(4- chlorobenzoyl)amino]benzamide (32) showed the most potent activity in this series.
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