Antihypertensive thiadiazoles. 2. Vasodilator activity of some 2-aryl-5-guanidino-1,3,4-thiadiazoles

DOI: 10.1021/jm00400a004

Source and publish data:

Journal of Medicinal Chemistry p. 906 - 913 (1988)

Update date:2022-08-04

Topics:

Authors:

Turner Turner

Myers Myers

Gadie Gadie

Hale Hale

Horsley Horsley

Nelson Nelson

Pape Pape

Saville Saville

Doxey Doxey

Berridge

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Article abstract of DOI:10.1021/jm00400a004

Some 2-aryl-5-guanidino-(or N-substituted guanidino)-1,3,4-thiadiazoles and closely related analogues were found to lower blood pressure in metacorticoid (DOCA) hypertensive rats. In the unsubstituted guanidines that exhibited low toxicity, optimum activi

Full text of DOI:10.1021/jm00400a004

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