Journal of Medicinal Chemistry p. 906 - 913 (1988)
Update date:2022-08-04
Topics:
Turner
Myers
Gadie
Hale
Horsley
Nelson
Pape
Saville
Doxey
Berridge
Some 2-aryl-5-guanidino-(or N-substituted guanidino)-1,3,4-thiadiazoles and closely related analogues were found to lower blood pressure in metacorticoid (DOCA) hypertensive rats. In the unsubstituted guanidines that exhibited low toxicity, optimum activi
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