European Journal of Medicinal Chemistry p. 1 - 13 (2015)
Update date:2022-09-26
Topics:
Ibrahim, Marwa A.
Abou-Seri, Sahar M.
Hanna, Mona M.
Abdalla, Mohamed M.
El Sayed, Nehad A.
Abstract Four series of condensed pyrrolo[1,2-c]pyrimidines 6a-d, 8a-d, 10a,b and 12a-e designed as PI3Kα inhibitors were synthesized and evaluated for inhibitory activity and selectivity toward different PI3K isoforms. The tested compounds displayed PI3K
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