Tetrahedron Letters p. 1857 - 1860 (1987)
Update date:2022-07-31
Topics:
Prasad, J. Siva
Liebeskind, Lanny S.
A highly stereoselective route to precursors of 1β-methylcarbapenems is described.Hydride reduction of a hexacarbonyldicobalt stabilized propargyl cation derived from a 4-acyl-2-azetidinone prepared using the Weinreb ketone synthesis proceeds with complete stereochemical control to a 1β-methylcarbapenem precursor bearing an alkynyl unit.The alkyne is readily elaborated to (3S,4R)-3-<(1R)-1-t-butyldimethylsilyloxyethyl>-4-<(1R)-1-methyl-3-methoxycarbonyl-2-oxopropyl>-2-azetidin-2-one or hydrogenated and oxidatively cleaved to (3S,4S)-3-<(1R)-1-t-butyldimethylsilyloxyethyl>-4-<(1R)-1-carboxyethyl>-azetidin-2-one.
View MoreFujian Wanke Pharmaceutical Co., LTD.
Contact:+86-598-5026002
Address:Economic development zone,jiangle county
Weifang Jahwa Chemical Co.,Ltd
Contact:0086-536-8897731,8897730
Address:No.5166 East Dongfeng Street,Weifang,Shandong,China
Guangxi Shanyun Biochemical Science and Technology Co., Ltd
Contact:+86-0772--6828887
Address:#2 Industrial Park of Luzhai County, Liuzhou, Guangxi, China
website:http://www.herbpurify.com
Contact:0086-028-85249238
Address:Room709-C1,Incubator Building, Tianfu Life Science Park No.88,Keyuan Road,Gaoxin district,Chengdu City,Sichuan Prov,China
Contact:17316303296
Address:240 Amboy Ave
Doi:10.1271/bbb1961.51.2055
(1987)Doi:10.1021/jo00245a020
(1988)Doi:10.1002/jhet.2792
(2017)Doi:10.1055/s-1987-28057
(1987)Doi:10.1016/S0040-4039(00)96308-1
(1987)Doi:10.1021/jo00245a036
(1988)
