Tetrahedron p. 2769 - 2778 (1987)
Update date:2022-08-03
Topics:
Epifani, Erbana
Florio, Saverio
Ingrosso, Giovanni
Sgarra, Riccardo
Stasi, Francesca
Mono- and bis-addition reactions of the β,γ-unsaturated Grignard reagents 2 and 6 to the C=N bonds of quinoxalines 1 afford high yields of dihydroquinoxalines 4 and tetrahydroquinoxalines 3.Dehydrogenation of 4g-l and 3a-c with DDQ leads to allylic quinoxalines 1i-m and 1e-g respectively in very good yields.Allylic and propargylic quinoxalines 1m and 1s can conveniently be synthesized by "cross-coupling" of 2-chloro-3-methylquinoxaline with 2c and 6a.
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Doi:10.1016/0223-5234(87)90263-7
(1987)Doi:10.1021/jo00243a050
(1988)Doi:10.1021/ja00215a066
(1988)Doi:10.1007/s10600-005-0017-y
(2004)Doi:10.1021/ja01307a052
()Doi:10.1021/ja00218a060
(1988)