Tetrahedron Letters p. 3795 - 3798 (1987)
Update date:2022-07-29
Topics:
Enders, Dieter
Demir, Ayhan S.
Puff, Heinrich
Franken, Sybille
An efficient and highly diastereo- and enantioselective annulation of cyclic 1.3-diketones to tetrahydro-quinolinediones of type 4 and 5 in good overall yields is described.The key step is the Michael addition of the corresponding lithiated SAMP-/RAMP-hydrazones to arylidenemalonates followed by lactamization with virtually complete asymmetric induction (de,ee<*>98percent).
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Doi:10.1021/ja00216a052
(1988)Doi:10.1021/acs.oprd.9b00438
(2020)Doi:10.1021/jo802650s
(2009)Doi:10.1135/cccc20080705
(2008)Doi:10.1039/b815831b
(2009)Doi:10.1246/bcsj.60.3453
(1987)
