
Tetrahedron Letters p. 3715 - 3716 (1987)
Update date:2022-08-04
Topics:
Cervello, Jordi
Marquet, Jorge
Moreno-Manas, Marcial
Protection of the diketone moiety of the polyketide model methyl 3,5-dioxohexanoate by copper(II) complex formation followed by alkylation of the free C-2 position results in overall regioselective alkylation of the diketoester to afford methyl 2-alkyl-3,5-dioxohexanoates, which under cyclization afford 3-alkyl derivatives of triacetic acid lactone.
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