Cycloaddition-promoted self-assembly of a polymer into well-defined β sheets and hierarchical nanofibrils

Article abstract of DOI:10.1002/anie.200805009

(Chemical Equation Presented) "Click" to fold: Cu ^I-catalyzed azide-alkyne cycloaddition polymerization of a peptide monomer induced folding of the resultant polymer into well-defined β sheets, which further self-assemble into hierarchical nanofibrils. The antiparallel β-sheet structure was confirmed by several techniques. Scanning probe micrographs confirm the formation of hierarchical amyloid-like nanofibrils.