Linear free energy relationship studies of enzyme active site binding: Thymidylate synthase

DOI: 10.1021/jm00401a013

Source and publish data:

Journal of Medicinal Chemistry p. 1141 - 1147 (1988)

Update date:2022-08-04

Topics: Enzyme Active site Thymidylate Synthase

Authors:

Chang Chang

Schwepler

Decedue Decedue

Balzarini

De Clercq

Mertes Mertes

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Article abstract of DOI:10.1021/jm00401a013

The requirements for active-site binding of thymidylate synthase from three sources, Lactobacillus casei, murine leukemia L1210, and human lymphoblast (Molt/4F), were investigated by analyzing the binding of a series of 5-(p-substituted phenyl)-2'-deoxyur

Full text of DOI:10.1021/jm00401a013

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