Linear free energy relationship studies of enzyme active site binding: Thymidylate synthase

DOI: 10.1021/jm00401a013

Source and publish data:

Journal of Medicinal Chemistry p. 1141 - 1147 (1988)

Update date:2022-08-04

Topics: Enzyme Active site Thymidylate Synthase

Authors:

Chang Chang

Schwepler

Decedue Decedue

Balzarini

De Clercq

Mertes Mertes

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00401a013

The requirements for active-site binding of thymidylate synthase from three sources, Lactobacillus casei, murine leukemia L1210, and human lymphoblast (Molt/4F), were investigated by analyzing the binding of a series of 5-(p-substituted phenyl)-2'-deoxyur

Full text of DOI:10.1021/jm00401a013

Products guided by the article

Product name:5'-Uridylic acid, 5-[4-(aminocarbonyl)phenyl]-2'-deoxy-

Cas No:113997-20-9

R&D Labs maybe for 113997-20-9

Shanghai Yuantai Chemical Products Co., Ltd

Contact:021--66129803

Address:Chengyin Road,Shanghai,China
Shifang Taifeng New Flame Retardant Co., Ltd

Contact:02884721008

Address:tingjiang industrial park, hefeng town
VanderArk International Limited

Contact:86-10-82437576

Address:Qing He
HAINAN JINYING IMPORT AND EXPORT CO. LTD

Contact:+86-898-32875423

Address:A SECTION 19TH FL, TIMES SQUARE, NO.2 GUO MAO AVENUE HAIKOU, HAINAN, P. R. OF CHINA
Chiral Quest (Suzhou) Company Ltd

website:http://www.chiralquest.com

Contact:+86-0512-62956066

Address:B1/9, 218 Xinghu Street, Suzhou Industrial Park

Relevant to this article

Doi:10.1021/ja00722a055
(1970)
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity

Doi:10.1021/jm00107a023
(1991)
Synthesis of polysubstituted benzothiophenes and sulfur-containing polycyclic aromatic compounds via samarium diiodide promoted three-component coupling reactions of thiophene-2-carboxylate

Doi:10.1021/jo0257849
(2002)
An improved synthesis of enantiopure 2-azabicyclo[2.2.1]heptane-3-carboxylic acid

Doi:10.1016/S0957-4166(02)00048-4
(2002)
Solid-phase synthesis of β-mannosides

Doi:10.1021/ja011406u
(2002)
A convenient and versatile method for the preparation of α-hydroxymethyl ketone derivatives from the corresponding allyl silyl ethers or allyl carboxylates

Doi:10.1002/jccs.200800134
(2008)

Article Doi