Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity

Article abstract of DOI:10.1021/jm00107a023

Since the hypothetical mechanisms of hydroperoxydation of arachidonic acid by, respectively, 5-lipoxygenase (5-LPO) and cyclooxygenase (CO) involve a redox cycle, a compound which reduces 5-LPO and CO to their inactive state would give a nonselective inhi