CONDENSATION REACTIONS INVOLVING THE α-METHYLENE GROUP IN SERIES OF 5-ALKYLPYRROLIDINE-2-THIONES AND 5-ALKYL-1-ACETYL-2-PYRROLIDONES

Article abstract of DOI:10.1007/BF00475357

It is shown that 1-substituted and N-substituted 5-R-pyrrolidine-2-thiones, in contrast to their oxygen analogs, undergo methylenethioalkylation and the Mannich and Michael reactions at the 3 position of the ring; this is due to their higher CH acidity.Th