THE REACTIVITY OF 1,4-DIHYDRONICOTINAMIDES TOWARDS REDUCTION OF 1,1',1''-TRIFLUOROACETOPHENONE: INFLUENCE OF METHYL SUBSTITUTION ON THE PYRIDINE RING.

Article abstract of DOI:10.1016/S0040-4039(01)80219-7

In a series of methyl substituted 1-(2',6'-dichlorobenzyl)-1,4-dihydronicotinamides those compounds with the methyl α to the pyridine nitrogen are at least one order of magnitude more reactive than the analogues without methyl or methyl on the 5-position.