A convenient synthetic method for fluorine-containing 4- alkoxydihydrobenzo[b][1,4]diazepinols and 3H-benzo[b][1,4]diazepines by the reaction of β-trifluoroacetylketene acetals with 1,2-phenylenediamines

DOI: 10.3987/COM-08-S(F)72

Source and publish data:

Heterocycles p. 983 - 990 (2009)

Update date:2022-08-04

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Authors:

Ota, Norio

Okada, Etsuji

Terai, Naoya

Miyamura, Tomomi

Shibata, Dai

Sakata, Tsuneaki

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Article abstract of DOI:10.3987/COM-08-S(F)72

β-Trifluoroacetylketene dialkyl acetals (3 and 5) reacted easily with various 1,2-phenylenediamines to give novel 4-alkoxy-2-trifluoromethyl-2,3- dihydro-1H-benzo[b][1,4]diazepinols (6 and 8) in moderate to high yields. Dehydration of 6 and 8 proceeded th

Full text of DOI:10.3987/COM-08-S(F)72

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