Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization

DOI: 10.1016/j.bmcl.2008.12.083

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1168 - 1172 (2009)

Update date:2022-08-02

Topics:

Authors:

Kattar, Solomon D.

Surdi, Laura M.

Zabierek, Anna

Methot, Joey L.

Middleton, Richard E.

Hughes, Bethany

Szewczak, Alexander A.

Dahlberg, William K.

Kral, Astrid M.

Ozerova, Nicole

Fleming, Judith C.

Wang, Hongmei

Secrist, Paul

Harsch, Andreas

Hamill, Julie E.

Cruz, Jonathan C.

Kenific, Candia M.

Chenard, Melissa

Miller, Thomas A.

Berk, Scott C.

Tempest, Paul

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Article abstract of DOI:10.1016/j.bmcl.2008.12.083

The successful application of both solid and solution phase library synthesis, combined with tight integration into the medicinal chemistry effort, resulted in the efficient optimization of a novel structural series of selective HDAC1/HDAC2 inhibitors by

Full text of DOI:10.1016/j.bmcl.2008.12.083

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