PEPTIDE SYNTHESIS BY PRIOR THIOL CAPTURE-V. THE SCOPE AND CONTROL OF DISULFIDE INTERCHANGE DURING THE ACYL TRANSFER STEP

Article abstract of DOI:10.1016/S0040-4039(00)96584-5

Disulfide interchange in DMSO, during amide formation by prior thiol capture is reduced to less than 3percent at low concentrations (<10 M) of substrate in the absence of air and light, and in the presence of 2.5 to 10 mole percent AgNO3.The rate and sele