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J = 16.0 Hz, 2H, CH2), 1.02 (s, 6H, 2CH3), 0.86 (s, 6H, 2CH3). 13
C
NMR (100 MHz, DMSO-d6) d: 194.5, 154.4, 143.6, 134.3, 128.2,
127.3, 112.7, 112.2, 49.6, 31.5, 31.0, 29.5, 26.7, 20.6. HRMS (ESI):
m/z calcd for: 378.2307, found: 378.2308.
Determination of X-ray crystal structures
2a. Growth of a single crystal was carried out in ethanol
at room temperature. Crystal data for C16H20N4, M = 268.36,
monoclinic, space group P21/n, a = 12.819(4), b = 8.441(3), c =
3
-1
˚
13.310(4), V = 1433.7(8) A , Z = 4, T = 298(2) K, m = 0.077 mm ,
7218 reflections measured, 2518 unique reflections, R = 0.0521,
Rw = 0.1342. CCDC 695205.
2b. Growth of a single crystal was carried out in ethanol
at room temperature. Crystal data for C12H12N4, M = 212.26,
monoclinic, space group P21/c, a = 9.698(5), b = 5.875(3), c =
3
-1
˚
10.023(5), V = 507.4(4) A , Z = 2, T = 298(2) K, m = 0.088 mm ,
2508 reflections measured, 890 unique reflections, R = 0.0410,
Rw = 0.1007. CCDC 695206.
3a. Growth of a single crystal was carried out in ethanol
at room temperature. Crystal data for C23H27BrN2O2, M =
443.38, orthorhombic, space group Pbca, a = 11.8053(10), b =
3
˚
15.6404(15), c = 2.432(2), V = 4141.8(6) A , Z = 8, T = 193(2)
K, m = 0. 2006 mm-1, 43797 reflections measured, 4743 unique
reflections, R = 0.0423, Rw = 0.0993.9
Acknowledgements
We are grateful to financial support from the National Science
Foundation of China (No. 20672090), Natural Science Foundation
of the Jiangsu Province (No. BK2006033), and Six Kinds of
Professional Elite Foundation of the Jiangsu Province (No. 06-
A-039).
10 For a review discussing 1,4-dihydropyridines, see: D. J. Triggle, Cell.
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