2-(2-Aryl-2-oxoethylidene)-1,2,3,4-tetrahydropyridines. Novel isomers of 1,4-dihydropyridine calcium channel blockers

DOI: 10.1021/jm00403a030

Source and publish data:

Journal of Medicinal Chemistry p. 1659 - 1664 (1988)

Update date:2022-08-05

Topics:

Authors:

Taylor Taylor

Badger Badger

Steffen Steffen

Haleen Haleen

Pugsley Pugsley

Shih Shih

Weishaar

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Article abstract of DOI:10.1021/jm00403a030

The title compounds are novel double bond isomers of 1,4-dihydropyridine-type calcium channel blockers (CCB). These derivatives were prepared by using the Hantzsch dihydropyridine synthesis. The assignment of structure was based on spectroscopic data and

Full text of DOI:10.1021/jm00403a030

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Product name:(3S,4S)-4-(2,3-Dichloro-phenyl)-6-methyl-2-[2-oxo-2-phenyl-eth-(Z)-ylidene]-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid diethyl ester

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