Novel DNA Analog for Potential Gene Regulating Agent. A Convenient Synthesis of α-Oligodeoxyribonucleotide Phosphorothioate Bearing 3'-Monophosphate

DOI: 10.1246/cl.1991.1941

Source and publish data:

Chemistry Letters p. 1941 - 1944 (1991)

Update date:2022-08-04

Topics: Synthesis Phosphorothioate

Authors:

Shinozuka, Kazuo

Morita, Tsutomu

Hirota, Yoshiki

Sawai, Hiroaki

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Article abstract of DOI:10.1246/cl.1991.1941

α-2'-Deoxyoctathymydilic acid phosphorothioate analog bearing 3'-monophosphate was conveniently synthesized via phosphoramidite method using a riboadenosine attached Teflon-based solid support.The obtained oligomer exhibited enhanced stability toward the digestion by common nucleases.

Full text of DOI:10.1246/cl.1991.1941

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