Novel DNA Analog for Potential Gene Regulating Agent. A Convenient Synthesis of α-Oligodeoxyribonucleotide Phosphorothioate Bearing 3'-Monophosphate

DOI: 10.1246/cl.1991.1941

Source and publish data:

Chemistry Letters p. 1941 - 1944 (1991)

Update date:2022-08-04

Topics: Synthesis Phosphorothioate

Authors:

Shinozuka, Kazuo

Morita, Tsutomu

Hirota, Yoshiki

Sawai, Hiroaki

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1246/cl.1991.1941

α-2'-Deoxyoctathymydilic acid phosphorothioate analog bearing 3'-monophosphate was conveniently synthesized via phosphoramidite method using a riboadenosine attached Teflon-based solid support.The obtained oligomer exhibited enhanced stability toward the digestion by common nucleases.

Full text of DOI:10.1246/cl.1991.1941

Products guided by the article

Product name:Phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

Cas No:114988-00-0

R&D Labs maybe for 114988-00-0

Zhongshan Haihong Medicine Co., Ltd.

Contact:86-0760-86925778 （0）18824993998

Address:A7 building,lianyuan road Torch Hi-tech Industrial Development Zone
Yuan Shi(SuQian)Biotechnology Co.,Ltd

website:http://www.yuanshibio.com

Contact:+86-527-84226672

Address:jiangsu suqian
Jiangsu Institute of Ecomones Co., Ltd

website:http://www.jsmone.com

Contact:+86-519-82821700

Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
Shenyang Xingzhenghe Chemical Co., Ltd.

Contact:024-23509232

Address:No. 33, Naner Road, Heping Dist.
Chengdu Boon Stream Chemical Industry Co.,Ltd.

Contact:+86-28-83156758

Address:No.859,Dongzikou Road,Jinniu District,Chengdu,Sichuan,P.R.China

Relevant to this article

A process for the rapid removal of dialkylamino-substituents from aromatic rings. Application to the expedient synthesis of (R)-tolterodine

Doi:10.1016/j.tet.2008.12.054
(2009)
C₁-symmetric diphosphite ligands derived from carbohydrates: Influence of structural modifications on the rhodium-catalyzed asymmetric hydroformylation of styrene

Doi:10.1002/ejoc.200801093
(2009)
Studies on the 1,2-brook rearrangement of bissilyl ketones

Doi:10.1055/s-0028-1087535
(2009)
Silyl ketene acetals/B(C₆F₅)₃ lewis pair-catalyzed living group transfer polymerization of renewable cyclic acrylic monomers

Doi:10.3390/molecules23030665
(2018)
Heteroleptic ytterbium(II) complexes supported by a bulky β-diketiminato ligand

Doi:10.1039/b818969b
(2009)
A re-engineering approach: Synthesis of pyrazolo[1,2-a]pyrazoles and pyrano[2,3-c]pyrazoles via an isocyanide-based four-component reaction under solvent-free conditions

Doi:10.1016/j.tetlet.2016.02.051
(2016)

Article Doi