Chemistry Letters p. 1941 - 1944 (1991)
Update date:2022-08-04
Topics: Synthesis Phosphorothioate
Shinozuka, Kazuo
Morita, Tsutomu
Hirota, Yoshiki
Sawai, Hiroaki
α-2'-Deoxyoctathymydilic acid phosphorothioate analog bearing 3'-monophosphate was conveniently synthesized via phosphoramidite method using a riboadenosine attached Teflon-based solid support.The obtained oligomer exhibited enhanced stability toward the digestion by common nucleases.
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