EFFICIENT SYNTHESIS AND ANTITUMOR ACTIVITY OF NOVEL 14-FLUOROANTHRACYCLINES

Article abstract of DOI:10.1016/S0040-4039(00)96527-4

The title compounds, (+)-14-fluoro-4-demethoxy- and (+)-14-fluorodaunorubicin, were synthesized from (-)-7-deoxy-4-demetoxy- and (-)-7-deoxydaunomycinone, respectively, by featuring the novel fluorination reaction in wich tetrabutylammonium fluoride is em