Journal of Organic Chemistry p. 4074 - 4081 (1988)
Update date:2022-08-04
Topics: Total synthesis Asymmetric Induction Double asymmetric induction acivicin
Mzengeza, Shadreck
Whitney, Ralph Allen
A total synthesis of acivicin, (αS,5S)-α-amino-3-chloro-4,5-dihydroisoxazole-5-acetic acid, has been achieved in 39percent overall yield from a derivative of (2S)-vinylglycine.The required diastereomer was obtained in an extremaly efficient manner <*>= 19
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