Synthesis of 1,1-difluoroethylsilanes and their application for the introduction of the 1,1-difluoroethyl group

DOI: 10.1016/j.jfluchem.2007.03.013

Source and publish data:

Journal of Fluorine Chemistry p. 1098 - 1103 (2007)

Update date:2022-07-29

Topics: Medicinal chemistry Characterization Protecting group Workup Starting Materials Reaction Functional Group Conversion Material Science

Authors:

Mogi, Ryo

Morisaki, Kazuo

Hu, Jinbo

Prakash, G.K. Surya

Olah, George A.

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Article abstract of DOI:10.1016/j.jfluchem.2007.03.013

1,1-Difluoroethysilanes (R₃SiCF₂CH₃, R = Me or Et) were synthesized from 1,1-difluoroethyl phenyl sulfone and chlorosilanes using magnesium metal via reductive 1,1-difluoroethylation. It was confirmed that 1,1-difluoroethylsilanes were effective 1,1-difluoroethylating reagents for carbonyl compounds.

Full text of DOI:10.1016/j.jfluchem.2007.03.013

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Product name:(1,1-difluoroethyl)trimethylsilane

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