Development of Conformationally Constrained Linear Peptides Exhibiting a High Affinity and Pronounced Selectivity for δ Opioid Receptors

Article abstract of DOI:10.1021/jm00118a005

A series of linear conformationally constrained opioid peptides was designed in an attempt to develop highly selective and potent agonists for the δ opioid receptors.These enkephalin analogues corresponding to the general formula Tyr-D-X(OY)-Gly-Phe-Leu-T