Tetrahedron p. 4979 - 4988 (1987)
Update date:2022-08-03
Topics:
He, Xu-Chang
Eliel, Ernest L.
Addition of Grignard and organolithium reagents to as well as hydride reduction of 2α-benzoyl-N-benzyl-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine (2, Y = C6H5CO) and addition of phenylmagnesium bromide to the corresponding 2-acetyl analog (11) proceed in highly diastereoselective fashion to produce virrtually exclusively the diastereomer predicted on the basis of Cram's chelate rule if chelation involves the ring oxygen atom.Mild acid hydrolysis of the adducts followed by selective oxidation produces highly enantiomerically pure α-hydroxyacids with clean recovery of the chiral adjuvant.
View MoreContact:18669908765
Address:Zibo City, Shandong Province, P.R.China
shijiazhuang alkay chemicals co..ltd(expird)
Contact:86-311-67692035
Address:2601,juntang building,qiaodong district,shijiazhuang
Contact:+86-512-69561895
Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China
Zhejiang Sanmei Chemical Industry Co., Ltd
Contact:86-579-87633213
Address:Huchu Industrial Zone, Qingnian Rd., Wuyi County, Zhejiang Prov., China.
website:https://www.synose.com/
Contact:86-579-82275537
Address:No.1958 Liyu Road , jinhua,zhejiang,China
Doi:10.1016/j.ejmech.2019.111849
(2020)Doi:10.1039/a900623k
(1999)Doi:10.1021/ja5026326
(2014)Doi:10.1021/ml5000096
(2014)Doi:10.1016/j.bmc.2014.04.054
(2014)Doi:10.1016/j.tetlet.2019.03.069
(2019)
