Oral Absorption of Cephalosporin Antibiotics. 2. Expanded Structure-Activity Relationships of 7-(Arylacetamido)-3-substituted Cephalosporins

Article abstract of DOI:10.1021/jm00118a023

The structure-activity relationship for 7-arylacetamido cephalosporins has been extended.Modifications of the 7-aryl group led to improvements in microbiological activity against Gram-positive organisms.However, Gram-negative activity was generally much p