
Tetrahedron Letters p. 5435 - 5436 (1987)
Update date:2022-07-31
Topics:
McKenzie, Thomas C.
Hassen, Wesley
Macdonald, Simon J. F.
The synthesis of the aglycone of the antibiotic Gilvocarcin-M by a sequential Meerwein Diels-Alder route is reported.The D-ring of the aglycone is attached by a halogen atom directed Meerwein arylation reaction and the A-ring is attached by a halogen atom directed Diels-Alder reaction.In the key step the directing chlorine atom is removed by a new thiophenylation reduction sequence.
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