Highly diastereoselective reduction of α-alkyl-β-hydroxy ketones with sodium and lithium boron hydrides via their titanium alcoholates

Article abstract of DOI:10.1016/S0040-4039(99)00308-1

The reduction of α-alkyl-β-hydroxy ketones is highly syn-selective if carded out in THF on their Ti-alcoholate complexes with LiBH₄ or L- Selectride or N-selectride depending on the bulkiness of the group bound to the carbonyl group.