A SHORT, ENANTIOSPECIFIC SHYNTHESIS OF THE 1α-HYDROXYVITAMIN D ENYNE A-RING SYNTHON

DOI: 10.1016/S0040-4039(00)96666-8

Source and publish data:

Tetrahedron Letters p. 4947 - 4950 (1987)

Update date:2022-07-29

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Authors:

Aurrecoechea, J. Miguel

Okamura, William H.

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Article abstract of DOI:10.1016/S0040-4039(00)96666-8

The vitamin D A-ring synthon, the enyne 3b, was synthesized in 5 steps (37percent overall yield) from (S)-(+)-carvone (5).The key step was the SmI2-Pd⁰ mediated transformation of epoxypropargyl ester 6 to 3b.

Full text of DOI:10.1016/S0040-4039(00)96666-8

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