Synthesis of a germination self-inhibitor, (-)-gloeosporone, and related compounds and evaluation of their activities

Article abstract of DOI:10.1248/cpb.40.524

Synthesis of (-)-gloeosporone (1a), isolated from spores of Colletotrichum gloeosporioides as a self-inhibitor for germination, and its three diastereomers was accomplished starting from (S)- and (R)-1-tridecen-8-ol obtained from their (S)-naphthyl ethylcarbamates (8a and 8b), both of which were isolated from the mixture of diastereoisomers derived from racemic 1-tridecen-8-ol (7) and the Pirkle reagent. Biological testing of the compounds showed weak self-inhibitor activity toward germination of the spores.

Full text of DOI:10.1248/cpb.40.524

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