Tetrahedron p. 613 - 618 (1988)
Update date:2022-07-31
Topics:
Tanner, David
Somfai, Peter
N-tosyl amides and lactams can be prepared easily and under mild conditions by the inter- or intramolecular condensation of carboxylic acids and secondary sulfonamides.The coupling reagent used is dicyclohexylcarbodiimide (DCC) in the presence of 4-pyrrolidinopyridine (4-PPY) and the reactions proceed readily, usually in high yield, at room temperature.
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Doi:10.3987/COM-08-S(D)54
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(2009)
