Molecules p. 2442 - 2461 (2008)
Update date:2022-07-30
Topics:
Sechi, Mario
Azzena, Ugo
Delussu, Maria Paola
Dallocchio, Roberto
Dessi, Alessandro
Cosseddu, Alessia
Pala, Nicolino
Neamati, Nouri
HIV-1 integrase (IN) is an attractive and validated target for the development of novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid. We performed a docking study to investigate the potential interactions of the title compounds with essential amino acids on the IN active site.
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