Journal of Medicinal Chemistry p. 841 - 846 (1989)
Update date:2022-07-31
Topics:
Baeckstroem, Reijo
Honkanen, Erkki
Pippuri, Aino
Kairisalo, Pekka
Pystynen, Jarmo
et al.
A series of disubstituted catechol derivatives was synthesized and tested as potential COMT inhibitors.The most active compounds were more than 1000 times more potent (IC 50 = 3-6 nM) in vitro than the known COMT inhibitor, 3',4'-dihydroxy-2-methylpropiop
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