Journal of Medicinal Chemistry p. 64 - 67 (1989)
Update date:2022-08-05
Topics:
Vennerstrom, Jonathan L.
Six model amine peroxides (4-9) were synthesized as targeted antimalarial oxidants.They were approximately 1 order of magnitude more potent than tert-butyl hydroperoxide (3) in vitro against Plasmodium falciparum, but like 3, they were inactive in vivo against Plasmodium berghei.
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