SYNTHESIS OF ISOQUINOLINES BEARING DIFFERENTIALLY FUNCTIONALIZED NITROGEN SUBSTITUENTS AT POSITIONS 3 AND 4 THROUGH AMINE DISPLACEMENT ON A 4-NITRO-3-(P-TOLUENESULFONYLOXY)ISOQUINOLINE

DOI: 10.1016/S0040-4020(01)85974-3

Source and publish data:

Tetrahedron p. 3391 - 3398 (1988)

Update date:2022-07-31

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Authors:

Hinkle, Jeffery S.

Lever, O. William

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Article abstract of DOI:10.1016/S0040-4020(01)85974-3

A method for the synthesis of isoquinolines functionalized with differentiated nitrogen substituents at positions 3 and 4 is described.The method involves tosylation of a 3-hydroxy-4-nitroisoquinoline and subsequent tosylate displacement by amine nucleoph

Full text of DOI:10.1016/S0040-4020(01)85974-3

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