Molecules 2020, 25, 1889
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3.3.2. Chemicals
Starting 4,4,6-trimethyl-6-phenyl-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-1,2(4H)-dione (10a),
4,4,6,9-tetramethyl-6-phenyl-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-1,2(4H)-dione (10b), 6-(4-chlorophenyl)
-4,4,6,8-tetramethyl-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-1,2(4H)-dione (10c) were provided by
Alinda Chemical Ltd., Moscow, Russian Federation. 5-Bromo-8-methoxy-4,4-dimethyl-6-methylene-5,6
-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-1,2(4H)-dione (12a), 5-bromo-8-fluoro-4,4-dimethyl-6-methylene
-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-1,2(4H)-dione (12b), 8-methoxy-4,4-dimethyl-6-((4-phenylpiperazine
-1-yl)methyl)-1H-pyrrolo[3,2,1-ij]quinolin-1,2(4H)-dione (14b) were prepared according to the reported
procedure [27]. Other reagents were purchased from commercial suppliers and used as received.
8-R-4,4-dimethyl-6-((4-R1-piperazine-1-yl)methyl)-1H-pyrrolo[3,2,1-ij]quinolin-1,2(4H)-diones
14a,c–f were obtained by our previously published procedure [27].
Ethyl 4-((8-Methoxy-4,4-dimethyl-1,2-dioxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-yl)methyl)piperazine-1
-carboxylate 14a. 0.75 g; yield 61 %; m.p. 156–158 oC; 1H NMR,
δ
(ppm): 1.16 (3H, t, J = 7.1 Hz, CH3CH2);
1.60 (6H, s, 2CH3); 2.32–2.40 (4H, m, CH2N); 3.20–3.42 (m, CH2N + H2O); 3.62 (3H, s, CH3O); 4.01
(2H, q, J = 7.1 Hz, CH3C 2); 5.64 (1H, s, H-5); 6.88 (1H, d, J = 2.4 Hz, H-7(9)); 7.25 (1H, d, J = 2.4 Hz,
H-7(9)). 13C NMR,
H
δ
(ppm): 15.0, 27.5, 43.9, 52.6, 56.2, 56.3, 59.5, 61.2, 106.7, 115.2, 119.9, 120.0, 124.4,
135.1, 142.5, 155.0, 156.1, 158.1, 183.3. HPLC-HRMS-ESI, m/z ([M + H]+), calcd for C22H27N3O5 + H+
414.2025, found 414.2022.
Ethyl 4-((8-Fluoro-4,4-dimethyl-1,2-dioxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-yl)methyl)piperazine-1
-carboxylate 14c. 0.81 g; yield 69%; m.p. 120–122 ◦C; 1H NMR,
δ
(ppm): 1.17 (3H, t, J = 7.1 Hz, C
1.62 (6H, s, 2CH3); 2.28–2.42 (4H, m, CH2N); 3.15–3.42 (m, CH2N + H2O); 4.02 (2H, q, J = 7.1 Hz,
CH3CH2); 5.68 (1H, s, H-5); 7.12–7.25 (1H, m, H-7(9)); 7.38–7.55 (1H, m, H-7(9)).13C NMR,
(ppm):
H3CH2);
δ
15.0, 27.6, 43.9, 52.6, 56.5, 59.4, 61.2, 109.5, 109.7, 115.7, 118.9, 119.1, 120.4, 120.5, 124.0, 135.7, 144.5,
155.0, 158.1, 160.0, 182.5. HPLC-HRMS-ESI, m/z ([M + H]+), calcd for C21H24FN3O4 + H+ 402.1825,
found 402.1824.
6-((4-Benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-yl)methyl)-8-methoxy-4,4-dimethyl-1H-pyrrolo[3,2,1-ij]quinolin
-1,2(4H)-dione 14d. 0.95 g; yield 67 %; m.p. 158–160 ◦C; 1H NMR,
δ (ppm): 1.62 (6H, s, 2CH3); 2.23–2.50
(4H, m, CH2N + DMSO-d5); 3.15–3.25 (2H, m, CH2N); 3.25–3.48 (m, CH2N + H2O); 3.72 (3H, s,
CH3O); 5.59 (1H, s, H-5); 6.69–6.72 (1H, m, CHarom); 6.78–6.82 (2H, m, CHarom); 6.87 (1H, d, J = 2.0 Hz,
H-7(9)); 7.24 (1H, d, J = 2.0 Hz, H-7(9)). 13C NMR,
δ (ppm): 27.5, 52.9, 53.0, 56.2, 56.3, 59.7, 62.1, 101.2,
106/6, 108.3, 109.5, 115.1, 120.0, 120.1, 122.4, 124.8, 132.5, 134.7, 142.5, 146.6, 147.6, 156.1, 158.1, 183.3.
HPLC-HRMS-ESI, m/z ([M + H]+), calcd for C27H29N3O5 + H+ 476.2182, found 476.2185.
6-((4-(4-Fluoropheny)lpiperazine-1-yl)methyl)-8-methoxy-4,4-dimethyl-1H-pyrrolo[3,2,1-ij]quinolin-1,2(4H)-dione
◦
1
14e. 0.79 g; yield 62 %; m.p. 180–182 C; H NMR,
δ (ppm): 1.62 (6H, s, 2CH3); 2.52–2.58 (4H,
m, CH2N); 3.02–3.08 (4H, m, CH2N); 3.27–3.33 (m, CH2N + H2O); 3.72 (3H, s, CH3O); 5.67 (1H, s,
H-5); 5.96 (2H, s, OCH2O); 6.98 (1H, d, J = 2.3 Hz, H-7(9)); 6.90–6.94 (2H, m, CHarom); 6.99–7.04
(2H, m, CHarom); 7.30 (1H, d, J = 2.3 Hz, H-7(9)). 13C NMR,
δ (ppm): 27.6, 49.6, 52.8, 56.2, 56.3, 59.6,
106.7, 115.2, 115.6, 115.8, 117.6, 116.7, 120.1, 124.7, 134.9, 142.5, 148.4, 155.5, 153.1, 157.4, 158.1, 183.3.
HPLC-HRMS-ESI, m/z ([M + H]+), calcd for C25H26FN3O3 + H+ 436.2032, found 436.2034.
6-((4-Benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-yl)methyl)-8-fluoro-4,4-dimethyl–1H-pyrrolo[3,2,1-ij]quinolin
-1,2(4H)-dione 14f. 0.91 g; yield 66 %; m.p. 160–162 ◦C; 1H NMR,
δ (ppm): 1.60 (6H, s, 2CH3); 2.25–2.46
(6H, m, CH2N); 3.20 (2H, s, CH2N); 3.22–3.35 (m, CH2N + H2O); 5.63 (1H, s, H-5); 5.96 (2H, s, OCH2O);
6.69–6.72 (1H, m, CHarom); 6.79–6.82 (2H, m, CHarom); 7.18 (1H, dd, J = 7.2 Hz (HF), J = 2.3 Hz, H-7(9));
7.84 (1H, dd, J = 10.3 Hz (HF), J = 2.3 Hz, H-7(9)). 13C NMR,
δ
(ppm): 27.6, 52.9, 53.0, 56.5, 59.5, 62.1,
101.2, 108.3, 109.5, 109.6, 115.6, 115.7, 118.9, 119.1, 120.5, 122.3, 124.3, 132.5, 135.3, 144.5, 146.6, 147.6,