Bioorganic and Medicinal Chemistry Letters (2021)
Update date:2022-08-04
Topics:
Nesaragi, Aravind R.
Kamble, Ravindra R.
Bayannavar, Praveen K.
Shaikh, Saba Kauser J.
Hoolageri, Swati R.
Kodasi, Barnabas
Joshi, Shrinivas D.
Kumbar, Vijay M.
Quinolin-3-yl-methyl-1,2,3-triazolyl-1,2,4-triazol-3(4H)-ones 8j-v were synthesized by click chemistry as an ultimate tactic where [3 + 2] cycloaddition of azides with terminal alkynes has been evolved. Herein, we are inclined to divulge the implication and prevalence of CuSO4·5H2O and THF/water promoted [3 + 2] cycloaddition reactions. The foremost supremacy of this method are transitory reaction times, facile workup, excellent yields (88–92%) with exorbitant purity and regioselective single product formation both under conventional and microwave method. Docking studies illustrated strong binding interactions with enzyme InhA-D148G (PDB ID: 4DQU) by means of high C-score values. The anti-tubercular and antifungal screening of synthesized compounds proclaimed promising activity. The in vitro and in silico studies imply that these triazoles appended quinolines may acquire the ideal structural prerequisites for auxiliary expansion of novel therapeutic agents.
View MoreNanjing Habo Medical Technology Co., Ltd.
Contact:025-85769882
Address:No.108. Ganjiabian east. Qixia District .Nanjing
Hangzhou Dawn Ray Pharmaceutical Co.,Ltd
website:http://www.dawnraypharma.com/
Contact:+86-571-85335020
Address:1018 Guangyin Building,No.42 E.Fengqi Road,Hangzhou,310012 China
Luzhou North Chemical Co., Ltd.
Contact:+86-830-2796784;+86-830-2796776
Address:Gaoba, Longmatan District, Luzhou, Sichuan Province
Suzhou Health Chemicals Co., Ltd.
website:http://www.healthchems.com
Contact:13776257979
Address:No. 338, Jingang Avenue,
Wuhan Better Organic Technology Inc.
Contact:13307163183
Address:Wuhan Economic&Technology Development Zone, Hubei
Doi:10.1021/ol0057838
(2000)Doi:10.1007/s00044-017-2050-3
(2018)Doi:10.1002/jlcr.1545
(2008)Doi:10.1038/aps.2013.104
(2013)Doi:10.1021/acs.cgd.8b00833
(2018)Doi:10.1063/1.464633
(1993)