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[a] All reactions were carried out under reflux for 8 h with a molar
ratio 2b/R-N3/CuCl/TEBA, 1:3:0.2:0.1. [b] Yield of isolated prod-
uct.
precursors, moderate to high yields, and chemoselectivity.
The imidation reaction proceeds only at the sp3 carbon
atom of the tertiary amines. We are currently investigating
the scope and applications of this reaction and the pharma-
cological activity of the products.
Supporting Information (see footnote on the first page of this arti-
cle): General procedure for the imidation of tertiary amines; char-
1
acterization data, including H and 13C NMR spectra.
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Received: February 12, 2009
Published Online: March 24, 2009
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