SYNTHESIS OF 2-AMINO-5-HYDROXY-4-PYRIMIDONES AND 5,6-BIHETEROARYLS USING p-NITROPHENYL 3-BROMO-2,2-DIETHOXYPROPIONATE (NPBDP)

Article abstract of DOI:10.1016/S0040-4020(01)85939-1

The reaction of NPBDP with various guanidines affords, after formic acid hydrolysis, 2-amino-5-hydroxy-4-pyrimidones.Reaction of NPBDP with o-aminoheterocycles gives similar results.NPBDP is readily converted to the 3-amino-2-alkenenitrile, 10, a key building block for the synthesis of 5,6-biheteroaryls.